The PAFAH1B1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to LIS1, MMS10-U, and PAFAH1B1. This antibody recognizes Human, Mouse, and Rat antigen. The PAFAH1B1 Antibody has been validated for the following applications: Immunohistochemistry.
Description
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum